RosettaFold3

RosettaFold3 (RF3) is a biomolecular structure prediction model, like AlphaFold3, that can fold proteins and other complex molecules, going from 1-dimensional information to 3D shape. RF3 consists of a diffusion-based neural network capable of predicting aRosettaFold3 (RF3) is a deep learning model for biomolecular structure prediction and modeling, designed to handle proteins, nucleic acids, and small-molecule ligands within the same framework. It is particularly well-suited for tasks that involve multi-chain protein complexes, protein–RNA and protein–DNA assemblies, and protein–ligand docking, making it valuable for drug discovery and structural biology applications, with benchmarking performance close to AlphaFold3.